Role of Autophagy in Cellular Senescence
Keywords:
Autophagy, Cellular senescence, Aging, Homeostasis, Therapeutic interventionsAbstract
This article investigates the role of autophagy in cellular senescence, a state of permanent cell cycle arrest that contributes to aging and age-related diseases. Autophagy, a cellular degradation process, is crucial for maintaining cellular homeostasis by removing damaged organelles and proteins. The study demonstrates how enhanced autophagy can delay the onset of senescence and promote cellular longevity. By elucidating the underlying pathways, this research offers potential strategies for therapeutic interventions targeting age-associated disorders through autophagy modulation.
References
Sharma, V. K., Basu, S., & Chakraborty, S. (2015). RNAi mediated broad-spectrum transgenic resistance in Nicotiana benthamiana to chilli-infecting begomoviruses. Plant cell reports, 34(8), 1389-1399.
Kumar, R. V., Sharma, V. K., Chattopadhyay, B., & Chakraborty, S. (2012). An improved plant regeneration and Agrobacterium-mediated transformation of red pepper (Capsicum annuum L.). Physiology and Molecular Biology of Plants, 18(4), 357-364.
Sharma, V., Zheng, W., Huang, J., & Cook, D. E. (2020). CRISPR-Cas RNA targeting using transient Cas13a expression in Nicotiana benthamiana. In RNA Abundance Analysis: Methods and Protocols (pp. 1-18). New York, NY: Springer US.
