Decoding the Spatiotemporal Dynamics of Autophagosomal Membrane Elongation in Response to Endoplasmic Reticulum Stress

Authors

  • Casey Perez Professor
  • Drew Hernandez Associate Professor
  • Pat Mitchell PhD

Keywords:

autophagosome biogenesis, endoplasmic reticulum stress, live-cell imaging, quantitative proteomics, cellular homeostasis

Abstract

This study elucidates the cellular mechanisms underlying autophagosomal membrane elongation triggered by ER stress. Utilizing advanced live-cell imaging and quantitative proteomics, we identified key regulatory proteins modulating membrane dynamics. Our findings reveal a novel interaction between ER-associated degradation pathways and autophagic processes, providing insights into potential therapeutic targets for diseases characterized by dysfunctional autophagy.

Author Biographies

Casey Perez, Professor

Professor
Ludwig Maximilian University of Munich
Geschwister-Scholl-Platz 1, 80539 München, Germany

Drew Hernandez, Associate Professor

Associate Professor
Massachusetts Institute of Technology
77 Massachusetts Avenue, Cambridge, MA 02139, USA

Pat Mitchell, PhD

PhD
University of Tokyo
7 Chome-3-1 Hongo, Bunkyo City, Tokyo 113-8654, Japan

References

Sharma, V. K., Kushwaha, N., Basu, S., Singh, A. K., & Chakraborty, S. (2015). Identification of siRNA generating hot spots in multiple viral suppressors to generate broad-spectrum antiviral resistance in plants. Physiology and Molecular Biology of Plants, 21(1), 9-18.

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Published

2024-10-22

Issue

Vol. 2 No. 3 (2024)

Section

Articles