Mitochondrial Dynamics and Its Role in Cellular Senescence: An Empirical Analysis of Mitophagy Modulation

Authors

  • Sam Davis PhD
  • Quinn Lopez Professor
  • Oliver Lewis Associate Professor
  • Riley Harris Dr. Sc

Keywords:

Mitophagy, Cellular Senescence, Mitochondrial Dynamics, Aging, Mitochondrial Quality Control

Abstract

Mitochondrial dynamics, particularly mitophagy, play a crucial role in cellular homeostasis and aging. This study examines the modulation of mitophagy and its effects on cellular senescence using advanced imaging techniques and mitophagy-deficient models. Our findings suggest a significant correlation between enhanced mitophagy and delayed senescence, highlighting potential therapeutic aspects for age-related diseases. The study provides novel insights into mitochondrial quality control mechanisms and their implications for cellular longevity.

Author Biographies

Sam Davis, PhD

PhD
Ludwig Maximilian University of Munich
Geschwister-Scholl-Platz 1, 80539 München, Germany

Quinn Lopez, Professor

Professor
Harvard University
Cambridge, MA 02138, USA

Oliver Lewis, Associate Professor

Associate Professor
University College London
Gower St, Bloomsbury, London WC1E 6BT, United Kingdom

Riley Harris, Dr. Sc

Dr. Sc
University of Melbourne
Parkville, VIC 3010, Australia

References

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Sharma, V. K., Kushwaha, N., Basu, S., Singh, A. K., & Chakraborty, S. (2015). Identification of siRNA generating hot spots in multiple viral suppressors to generate broad-spectrum antiviral resistance in plants. Physiology and Molecular Biology of Plants, 21(1), 9-18.

Sharma, V.K.; Marla, S.; Zheng, W.; Mishra, D.; Huang, J.; Zhang, W.; Morris, G.P.; Cook, D.E. CRISPR guides induce gene silencing in plants in the absence of Cas. Genome Biol. 2022, 23, 6.

Published

2024-12-18

Issue

Section

Articles