Mitochondrial Dynamics in Stem Cell Differentiation

Authors

  • Jesse Jones
  • Robin Gonzalez
  • Pat Edwards

Keywords:

mitochondria, stem cells, differentiation, fission, fusion

Abstract

This study explores the pivotal role of mitochondrial dynamics within the process of stem cell differentiation. By utilizing high-resolution imaging techniques and metabolic assays, we identified how mitochondrial morphology changes during the transition from pluripotent stem cells to specialized somatic cells. The results reveal the intricate balance between fission and fusion events that dictate cellular fate. Implications for regenerative medicine and cellular therapies are discussed, highlighting the potential to manipulate mitochondrial dynamics to favor desirable differentiation outcomes.

Author Biographies

Jesse Jones

PhD in Molecular Biology
Ludwig Maximilian University of Munich
Geschwister-Scholl-Platz 1, 80539 München, Germany

Robin Gonzalez

PhD in Biochemistry
Taras Shevchenko National University of Kyiv
Volodymyrska St, 60, Kyiv, Ukraine, 01601

Pat Edwards

PhD in Cellular Biology
Harvard University
Massachusetts Hall, Cambridge, MA 02138, USA

References

Sharma, V. K., Marla, S., Zheng, W., Mishra, D., Huang, J., Zhang, W., ... & Cook, D. E. (2022). CRISPR guides induce gene silencing in plants in the absence of Cas. Genome Biology, 23(1), 6.

Published

2023-08-14

Issue

Section

Articles